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Copper Peptide-GHK CU Applied In Cosmetics Industry
Nov 20, 2018

Background and overview of  copper peptide GHK-CU

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GHK is a tripeptide molecule, and the sequence is glycyl-histidyl-lysine. It is naturally present in human blood, saliva and urine. By age 20, the concentration of GHK in the blood is At 200ng/mL (10-7 M), the concentration drops to 80ng/mL at 60 years old. This decline is directly related to a significant decline in organ regeneration. In 1973,Pickart was first isolated from ghk-cu, a tripeptide found in studies of active substances that also act on aging tissue and young tissue. Subsequent studies have shown that the sequence of this tripeptide isGlycyl-l-histidyl-l-lysine has a strong affinity with copper ions, forming a ghk-cu complex. Research proves that GHK ts functions as a complex with copper ions.


GHK originally isolated from human plasma in 1973, and found that it has the function of wound repair in 1985, 1999, the researchers think that GHK copper and its compounds can be used as tissue remodeling of activator, it is also a signal peptide, promote scar outside a large number of the degradation of collagen protein concentration, normal skin synthesis of collagen and elastin, proteoglycan and grapes glycosaminoglycans generated, different cell types of the growth rate and migration, anti-inflammatory, oxidation reaction.


The nature of thePeptides GHK - Cu for organisms to produce) in the (blood, saliva, can effectively promote the Collagen, Collagen and Elastin (Elastin) manufacturing, increase blood vessel growth and antioxidant capacity, and stimulate glucose polyamine (Glycosaminoglycans,


GAGs) produced to help the skin recover its ability to repair itself. Ghk-cu is also an important factor in helping injured tissues fight inflammation in humans, playing an important role in stimulating the production of normal proteins to replace damaged ones.


It's made up of a few amino acids with a particular sequence that are connected by an arrangement of amide bonds, two amino acids that are called dipeptides, three amino acids that are called tripeptides, and so on. Even identical amino acids, if arranged in different ways, will form very different peptides.


Cupric peptides (tripeptide - copper) are the first progenitors of peptides, which are actually small protein molecules made of amino acids that are more easily absorbed by the skin. Peptides are made by combining amino acids with specific sequences arranged by amide bonds; two amino acids are called dipeptides; three amino acids are called tripeptides; and so on. Even identical amino acids, if arranged in different ways, will form very different peptides. Tripeptide - copper, copper is the trace element needed to maintain body function (2 mg daily), function is very many and complex, it is the element that various cell enzyme action needs. In the role of skin tissue, there are antioxidant, promote collagen hyperplasia, and help wound healing function.


This breakthrough copper peptide can increase the vitality of cells without hurting and stimulating the skin, gradually repair the lost collagen in the body, make the subcutaneous tissue strong and the wound heal rapidly, and then achieve the purpose of removing wrinkle and anti-aging.


Applications


Treatment for allergies, repair, red blood silk, acne, diminish inflammation, nutrition skin cells, enhance skin cells resistance, improve skin resistance, can also be used to repair the spot after remove red dot mole anti-inflammatory, photoelectric project instrument repair the skin before and after operation, tattoo repair nursing after operation, faded red tramal as powerful organization protection and antiphlogistic, protect the injured tissue from oxidative damage to signal further, transfer damaged proteins and scar tissue, and normal tissue instead, prompting macrophages into the injured area, the release of growth ginza proteins stimulate hair follicles, hair growth. It also has the effect of polypeptide GHK to promote the synthesis of type I collagen. Suitable for reducing inflammation and repairing, promoting wound healing and reducing scars. Promotes hair growth and reduces hair loss. Reduce wrinkles and improve skin elasticity.


Specially added can effectively promote the Collagen, Collagen and Elastin (Elastin) manufacturing, increase blood vessel growth and antioxidant ability, and stimulate glucose polyamine (Glycosaminoglycans,


GAGs) produced to help the skin recover its ability to repair itself. The rare blue copper peptide with the function of cell reactivation and regeneration, combined with the unique characteristics of various plants, will achieve the maximum effect of wrinkle removal.


Cupride-containing skin care products have the following effects:


Tighten loose skin and improve elasticity


Improve skin clarity


Increases skin density and tightness


Reduce light damage and spots;


Reduce fine lines and deep wrinkles


Greatly increases the proliferation of keratinocytes


A large number of clinical studies have found that ghk-cu can improve the skin quality of women around 50 years old


Clinical application of Copper peptide is immunohistochemistry of biopsy samples. The experimental process is as follows. After using the ghk-cu cream on the thigh for one month, ghk-cu has obvious effect of promoting collagen synthesis. GHK - Cu on Vitamin C was effective for 50 percent of women and retinoic acid was effective for 40 percent of women. Seventy-one women with mild or severely aged facial skin used ghk-cu facial cream 12 Skin aging improved significantly after week. Ghk-cu improves skin laxity, clarity and appearance, reduces the depth of fine lines and wrinkles, and increases skin density and thickness. 41 women with mild or severely aged facial skin were used


After 12 weeks of the eye cream, compared with the control group using vitamin K, ghk-cu showed significant effect in wrinkle resistance and increased skin density and thickness. In another set of experiments, 61 were 50 to 50 years old


Women aged between 59 use ghk-cu every day


The clarity of skin firmness is improved, fine lines are reduced, roughness is reduced, pigmentation is improved, and skin density and thickness are increased. The results of a chemical biopsy suggest that the cream can stimulate keratinocyte proliferation.


The results of these experiments can prove that the ghk-cu cream has the following effects:


(1) the skin is firm and elastic.


(2) improve skin density and toughness.


(3) reduce fine lines and deep lines.


(4) improve brightness.


(5) reduce pigmentation and spots.


(6) significantly increased proliferation of keratinocytes.


Preparation and mechanism of action


Ghk-cu can pass through the stratum corneum and is sufficient in number to activate regeneration. Permeability increases as pH increases. Research proves that GHK and ghk-cu


It can pass through the stratum corneum, however, because of the ease of enzymatic hydrolysis, it is important to ensure that there is sufficient absorption of copper peptides. Arul et al. treated dermal wounds with a biotinized copper peptide binding to a collagen matrix, their study found


Ghk-cu improves wound contraction and increases cell proliferation and antioxidant enzyme expression. Recent studies have looked at the stable conditions of ghk-cu: easy hydrolysis under oxidation conditions, in water or at pH


4.5-7.4 in the buffer, 60 ℃ can be saved under the condition of two weeks. The distribution coefficient of octanol - phosphate buffer salt indicates that GHK-Cu


It is highly hydrophilic and is not very stable under the condition of negatively charged lipid diacetyl phosphate. Ghk-cu microspheres coated with hydroxypropyl cellulose were used as colonic targeted release drugs. GHK Cu -


The release was influenced by the level of cross-linking and the amount of drug loading, and the microspheres released 50-80% of the drug within 4 hours. These studies suggest that ghk-cu can be used as a dietary supplement.


Usage and dosage


Skin repair peptide 1 bronze peptide powder as a product, in the production of the final phase of cosmetics can join, preparation temperature below 40 ℃, it is recommended to use concentration: 500 PPM to 2000 PPM.


Storage and shelf life


Copper peptide powders must be stored in a cool, dark and clean place to ensure a minimum shelf life of 12 months. Long-term storage, the proposal in 4 ℃, shelf life can be extended to at least 24 months.


Method of use


By means of temperature conduction, the skin is white and red through fingers absorption.


1. Knead: press the appropriate amount on the palm, and gently knead with both hands warm.


2. Temperature: gently turn the gel texture into water crystal dew with warm handle.


3. Massage: apply both hands to both cheeks and the whole face evenly.


4. Touch: gently massage from inside to outside in the way of the day circle of the finger abdomen until it is absorbed.


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