Introduction of Cosmetic peptide
1. Introduction of peptides
Cosmetic peptide (cosmetic peptide) is a small decomposed collagen molecule containing amino acid groups. It is generally composed of 2-10 amino acids. Peptides are also naturally present in the human body. Peptides are chains of amino acids. The protein we're familiar with is a polypeptide chain.
Peptides are made up of amino acids linked together by peptide chains, but each peptide can be made up of many different amino acids. Two amino acids are called dipeptides, three amino acids are tripeptides, and so on. And at present often hear of 3 win peptide, 5 win peptide, even 9 win peptide, belong to oligosine peptide chain. Each oligopeptide chain has a different effect. Peptides with less than 10 amino acids are called oligopeptides, peptides with more than 50 amino acids are called proteins. Because the variety that contains amino acid is different, 2 win peptides, 3 win peptides to also have different breed, appeared consequently now have all sorts of action, all sorts of name "win peptides".
Peptides are involved in various fields of human hormones, nerves, cell growth and reproduction. Their importance lies in the adjustment of physiological functions of various systems and cells in the body, the activation of relevant enzyme systems in the body, the promotion of the permeability of intermediate metabolic membranes, or the control of DNA transcription or the influence of specific protein synthesis, and ultimately the production of specific physiological effects.
2. The cosmetic effect of peptides in cosmetics
The biological activity of peptides depends on their amino acid composition and sequence. Almost all physiological processes in human body are regulated by peptides or proteins composed of specific amino acid sequences. Therefore, bioactive peptides have become a new direction and idea of cosmetics research and development and application, and their functions are more and more subdivided, such as: anti-aging, anti-allergy, repair, anti-oxidation, anti-edema, promote hair regeneration, inhibit melanin generation, breast enlargement, weight loss, etc.
The skin is the natural barrier that human body resists external environment encroachment, have certain protective effect to external stimulation, this benefits from the protective effect of skin dense cuticle. But because this also blocks the nutrient composition of cosmetic in skin surface, nutrient material needs to permeate corneous layer membrane ability to enter dermis, macromolecules and fat soluble material are absorbed only a few can pass pore, sweat hole. So we usually use cosmetics, most just stay on the surface of the skin, and with biological activity of beauty peptide, but can be more easily through the cuticle gap into the dermis, thereby playing a role.
Peptides were originally directly used in some European and American cosmeceuticals. The mechanism of action is similar to that of proteins, which can promote the proliferation of collagen, elastic fiber, polysaccharide and hyaluronic acid, improve the moisture content of skin, increase skin thickness and reduce fine lines. Because the kind that contains amino acid is different, can produce different action consequently, satisfy the demand of skin different function.
Iii. Functional classification of peptides:
Three kind of snake venom peptide SYN - AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
Snake venom tripeptide partially blocks nerve transmission of muscle contraction signals, affects nerve conduction of skin and soil, relaxes facial muscles, and smoothes dynamic, static and fine lines.
Acetyl hexapeptide- 8 (Acetyl hexapeptide-3 = ac-eemqrr-nh2, nickname Argireline)
Acetyl hexapeptide-8, also known as botulinum toxin, has the effect of inhibiting the excessive release of nerve substances and affecting the protein transfer between subcutaneous nerves and muscles. It has the best effect on slowing down the crow's feet, decree lines and other dynamic lines of the face. According to the research of French dermatologists, hexapeptide has a particularly obvious effect on the wrinkles around the eyes.
Promote protein, polysaccharide and hyaluronic acid synthesis, improve skin quality
Three peptides GHK (Aldeline)
Tripeptides are the earliest known peptides, which are regarded as growth factors and can stimulate the production of glucosamine polyacid and collagen. It was isolated from wound healing tissue in 1990 and has the effect of promoting wound healing and hyperplasia.
(peptide = GHK cooper - Cu)
Blue copper peptides are the perfect combination of bivalent copper ions and tripeptides
Copper peptides were first used as internal medicine to treat gastric ulcers. Copper is one of the body's basic elements, and it helps heal wounds in the way skin tissue functions. Copper ions cannot enter into the bottom layer of the skin alone. Therefore, through the blue copper peptides linked by glycine, ionine and histidine, copper ions can be imported into the skin to give full play to the efficacy of skin revitalization. Blue copper peptides can effectively promote the production of collagen and elastic protein and antioxidant energy, and penetrate deeper into the skin, promote self-repair ability, and play an extreme role in smoothing wrinkles.
Hexapeptide-9 can promote collagen production and epidermal differentiation and significantly resist wrinkles. Strong repair (especially for acne marks repair has a very strange effect); Fight skin flabby, make the skin has flexibility, firmer.
Matrixyl Pentapeptide-3 = Matrixyl -KTTKS of Palmitoyl Pentapeptide-3
Palmitoyl pentapeptide-3 is the first to be used in dermatology and medicine with vitamin A and other anti-aging ingredients, it can directly act on the dermis, promote collagen and polysaccharide hyperplasia, to achieve skin tightening purposes, and other moisturizing ingredients together, can accelerate the tightening effect of pull.
Anti - inflammatory reaction, remove red blood, reduce allergic discomfort
Acetylhexapeptide-49 reduces the activity of protease-activated receptor 2 (par-2), reduces the release of pro-inflammatory intermediates CGRP,IL6, and IL8, and reduces neuroinflammatory reactions and allergic skin pain, itching, and other discomfort.
Acetyltetrapeptide-40 reduces red blood lines and capillaries on the face, improves skin tone, and has a tightening and anti-aging effect.
Peptide -36 (Palmitoyl tripeptide-36)
Palmitoyl tripeptide-36 has a broad spectrum of antimicrobial properties, which can effectively inhibit pseudomonas aeruginosa, acne bacillus and other pathogenic bacteria.
Remove eye bags and dark circles
Acetyl - 5 (Eyeseryl) and four peptides eye silk peptide Eyeliss ammonia
Acetyltetrapeptide-5, palmitotetrapeptide-7, and dipeptide VW improve eye lymph microcirculation, skin elasticity, and anti-edema function, so they are used to relieve eye bags and dark circles.
Palmitoyl oligopeptide promotes the proliferation of collagen and hyaluronic acid, and improves skin moisture and elasticity.
Acetyldipeptide-13 inhibits elastase activity, enhances skin's ability to resist stretching, and maintains elasticity and tightness.
Palmitoyl Tetrapeptide pal-gqpr (Palmitoyl Tetrapeptide 3)
Palmitoyl tetropeptide-3 is similar to DHEA in its efficacy in regulating inflammatory factors and restoring skin youth and firmness.
Whitening, removing spots and brightening the skin
Nine peptide 1 (Nonapeptide - 1)
When the skin by external stimuli or ultraviolet light, located in the basal layer cells of alpha melanocyte stimulating hormone will be combined with receptors on the melanocytes, direct stimulation of melanin cells, activate the tyramine acid, begin to secrete black element, nine peptide can block, suspension in the melanin formation source of alpha melanocyte stimulating hormone message transmission, avoid and melanin cell receptors, in order to reduce the melanin.
Acetylhexapeptide-38 can significantly stimulate the synthesis of fat at the site of use, increase the volume of chest, hips or cheeks, and create a perfect body curve.
Remove orange peel
Acetylhexapeptide-39 inhibited the expression of peroxisomal proliferating activated receptor gamma coactivator alpha (pgc-1 alpha), reduced the differentiation and maturation rate of adipocytes, and slowed down the accumulation of lipids in adipose tissue.
Light aging resistance
Three peptides - 33 (Preventhelia)
Tripeptide-33 can reduce the damage of cell DNA and protein directly or indirectly caused by ultraviolet radiation, and effectively fight against photoaging.
Acetylhexapeptide-51 protects DNA from damage, promotes natural DNA repair and enhances the life span and vitality of cells. Acetylhexapeptide-51 can effectively repair the aging skin cell performance, restore the skin cell youth, prevent skin damage, prolong the cell life, so that you have 50 years of age 30 years of skin.
Promote hair eyelash growth
Myristic-pentapeptide-17 activates the keratin gene, which promotes the growth of eyelashes, eyebrows and hair.
Fight against stress, suitable for office workers
Also known as acetyltetrapeptide-22 (Thermostressine).
Acetyltetrapeptide-22 increases the level of heat shock protein 70 in the skin, giving the skin the ability to cope with daily stress stimuli and challenges. It is especially suitable for improving the fragile, tired and dull skin and restoring its vitality.
Resitance to carbonylation and oxidation
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