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Do You Know Peptides Used In Cosmetics
Jul 28, 2018

As you know, the basic substance of life is a protein, which is made up of amino acids with a certain sequence, two amino acids are called dipeptide, three amino acids are called tripeptide, and three (containing) more amino acids are condensed into a peptide called polypeptide. So, in general, a peptide is a combination of more than two amino acids.

Peptides as the main ingredient of biological skin care products, most of the bioactive peptides is cell growth factor, they very micro levels in the body, but very high biological activity, on physiological function and metabolic activity of cells play a role of biological regulation, direct impact of various types of cell growth, division, differentiation, proliferation and migration, in beauty, plastic surgery, burns, ulcers and various skin diseases play an important role in wound repair and healing.

Polypeptide species

Several kinds of bioactive polypeptides related to skin so far, dozens of bioactive polypeptides have been found in researches. They are often added to beauty and skin care products.

Insulin-like growth factor -1 (igf-1). Together with other cytokines, igf-1 affects the growth and development of bone and cartilage. Igf-1 ACTS as a chemotaxis for endothelial cells and stimulates DNA synthesis, which can speed up the division and proliferation of different types of cells, increase the synthesis of proteins and steroids, and play a role in wound repair and nerve cell reconstruction.

Fibroblast growth factor (FGF), including both acidic (aFGF) and alkaline (bFGF), is a multifunctional cytokine derived from the mesoderm and neuroectoderm and is a highly potent mitogen. It has a pro-division effect on vascular endothelial cells, fibroblasts, myoblasts, osteoblasts, etc., and through its chemotaxis and pro-cell migration, macrophages, mesenchymal cells, endothelial cells, fibroblasts, etc. can gather to the wound site to initiate the wound healing process. Promote the formation of new blood vessels, promote the release of cells collagen enzyme, blood plasmin activator. When combined with heparin, the biological activity of FGF increased by 20 ~100 times.

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Epidermal cell growth factor (EGF). As a mitotic source, EGF can promote cell division and differentiation and promote epidermal wound healing. EGF can promote the transport of small molecules such as K+, deoxyglucose and epoxy-aminoisobutyric acid, increase the synthesis and secretion of extracellular matrix, and promote the synthesis of RNA, DNA and proteins.

Transforming growth factor - at (TGF- at). During embryonic development, TGF- ogues regulate cell proliferation and differentiation, promote the formation of collagen fibers, reticular fibers and elastic fibers, and regulate the synthesis and secretion of collagen, fibronectin, proteoglycan and mucopolysaccharides. TGF- scaffold involves chemotaxis, proliferation and differentiation of multiple cells, and is involved in post-traumatic epithelial regeneration, interstitial hyperplasia, and angiogenesis.

Platelet derived growth factor (PDGF). PDGF is an activator of mesenchymal cells involved in tissue reconstruction during wound healing and osteogenesis. PDGF enables connective tissue cells such as fibroblasts, arterial smooth muscle cells, synovial cells, and neuroglia cells to aggregate to the site of injury, where they differentiate and proliferate. It also inhibits the dissolution of connective tissue cells, prolongs their survival time, thus selectively stimulates the growth of connective tissue cells, and promotes the repair and healing after tissue injury. Synergistic effect of PDGF and IGF on epidermal and endothelial regeneration.

Keratinocyte growth factor (KGF). KGF is purified from fibroblast culture medium and is the most important influencing factor in the formation of keratinocytes and hair follicles, which stimulates DNA synthesis and promotes the growth of human keratinocytes, epidermal cells and epithelial cells. KGF dysfunction can lead to epidermal atrophy, hair follicle abnormalities, and dermal damage. KGF plays an important role in the regulation of epidermal keratinocytes proliferation and wound healing.

he role of beauty care Bioactive polypeptides can balance the distribution of pigment, improve skin quality and make skin smooth and ruddy. Adding a certain amount of bioactive polypeptides in beauty and skin care can supplement the necessary nutrients of skin cells at any time, maintain the exuberant vitality of skin cells, and maintain the elasticity and luster of skin cells.

At the same time, polypeptides have outstanding effects on the repair of various kinds of skin wounds (including sunburn, acne, peeling, redness and acid) after skin exchange and deep skin injury after grinding. Bioactive peptides can directly affect the damaged cellular tissues, promote the growth of fibroblasts, promote the division and proliferation of collagen cells and keratinocytes, and quickly repair the deep damaged tissues of the skin, repair the skin damage and accelerate the wound healing.


The effect of bioactive polypeptides is summarized as follows:

The epidermal level of the epidermis in the epidermis affects the activity and growth factors of keratinocytes, stimulates keratinocytes migration and epithelialization, stimulates epidermal cell differentiation and correction, and strongly promotes epidermal repair and healing.

Mylar stimulates fibroblast activity at dermal level, enhances extracellular matrix contraction and construction, provides skin nutrients and promotes skin wound healing and functional regeneration.

On the overall level of skin, this product strengthens the resistance to environmental invasion, ultraviolet light, pollutants, irritants, allergens and inflammatory cells, strengthens and strengthens skin tendons, enhances skin elasticity, stimulates scar tissue discoloration, reduces scar formation, and delays skin aging.