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Angiotensin Acetate CAS 90779-69-4 Generic peptide Supplier Quality guaranteeChat Now
Base information of Angiotensin Acetate
Chemical Name： Angiotensin Acetate
CAS NO. 90779-69-4
Molecular Formula ：C43H67N11O12S2
Molecular Weight： 994.19
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Specifications Of Atosiban Acetate
Specific Rotation(20/D) -
Single Impurity(HPLC) 1.0%
Amino Acid Composition 10% of theetical
Peptide Content(N%) 80%(by %N)
Water content(Karl Fischer) 8.0%
Acid content(HPLC) 10.0%
Mass balance 95.0~105.0%
Atosiban (trade names Tractocile, Antocin, atosiban SUN) is an inhibitor of the hormones oxytocinand vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to haltpremature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. It was developed by Ferring Pharmaceuticalsin Sweden and first reported in the literature in 1985.Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women.
Function & Application
Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane.
Atosiban is useful in improving the pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with repeated implantation failure (RIF). The pregnancy rate improved from zero to 43.7%.
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